HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylsilyldiazomethane → Methyl 2-(4-fluorophenyl)-2-oxoacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethylsilyldiazomethane | HCID 167693 | — |
| Reactant | 2-(4-Fluorophenyl)-2-oxoacetic Acid | HCID 579440 | — |
| Reactant | Diethylether hexane | HCID 21584099 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | Methyl 2-(4-fluorophenyl)-2-oxoacetate | HCID 10965144 | — |
Reaction Steps
To a solution of 4-fluorophenyl glyoxylic acid (100 mg, 0.595 mmol) in ethyl ether (5 ml) was added trimethylsilyl diazomethane (2 M/hexane, 1 ml) at 0° C. TLC showed reaction was complete after 1 h. The ether was evaporated to leave a yellow oil. Chromatography with hexane/ether (95:5) gave methyl 4-fluorophenylglyoxalate as a pale yellow oil (75 mg). 500 MHz 13C NMR (CDCl3): δ 184.11; 167.85; 165.79; 163.59; 133.04; 132.96; 128.97; 116.33; 116.16; 115.90; 115.72; 52.85.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06420418B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-e62bb20f46c34ecaae120fbc72883c9e |
| Source note | uspto-grants-2002_07 |