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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2229491Generated: October 31, 2026

Methyl 2-hydroxy-2-(4-methoxyphenyl)acetate → 2-(3,5-Dimethoxyphenyl)-2-tetrahydrofuroic acid

https://huagongshe.com/reaction/2229491

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 2-hydroxy-2-(4-methoxyphenyl)acetateHCID 523496—
ReactantMethyl 2-(3,5-dimethoxyphenyl)-2-hydroxyacetateHCID 62214124—
Product2-(3,5-Dimethoxyphenyl)-2-tetrahydrofuroic acidHCID 18467866—

Reaction Steps

2-(3,5-Dimethoxyphenyl)-2-tetrahydrofuroic acid was prepared according to the procedures described in Reference Example 27 substituting 3,5-dimethoxymandelic acid, methyl ester for 4-methoxymandelic acid, methyl ester in Step A.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06420418B1
Source datasetuspto-grants-2002_07
ORD IDord-342b9add2ed5478aac2b0fbe2853b273
Source noteuspto-grants-2002_07