4-(N-Boc-amino)piperidine → HCID 11948280, compound

HRID 222950Notes

Reaction equation

HRID 222950 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[N:9]1[C:14]2[N:15]=[C:16](S(C)(=O)=O)[N:17]=[C:18]([C:19]3[CH:20]=[C:21]([NH:26][C:27](=[O:36])[C:28]4[CH:33]=[CH:32][C:31]([F:34])=[C:30]([CH3:35])[CH:29]=4)[CH:22]=[CH:23][C:24]=3[CH3:25])[C:13]=2[CH:12]=[CH:11][C:10]1=[O:41].[NH:42]1[CH2:47][CH2:46][CH:45]([NH:48]C(=O)OC(C)(C)C)[CH2:44][CH2:43]1>>[NH2:48][CH:45]1[CH2:46][CH2:47][N:42]([C:16]2[N:17]=[C:18]([C:19]3[CH:20]=[C:21]([NH:26][C:27](=[O:36])[C:28]4[CH:33]=[CH:32][C:31]([F:34])=[C:30]([CH3:35])[CH:29]=4)[CH:22]=[CH:23][C:24]=3[CH3:25])[C:13]3[CH:12]=[CH:11][C:10](=[O:41])[N:9]([C:3]4[C:2]([F:1])=[CH:7][CH:6]=[CH:5][C:4]=4[F:8])[C:14]=3[N:15]=2)[CH2:43][CH2:44]1

Participants

3

Reactant 2

HCID 7238334-(N-Boc-amino)piperidineHCID 11947858HCID 11947858, compound

Product 1

HCID 11948280HCID 11948280, compound

Procedure

The title compound was prepared as described in Example 2 from N-{3-[8-(2,6-difluorophenyl)-2-(methylsulfonyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methylphenyl}-4-fluoro-3-methylbenzamide and 1,1-dimethylethyl 4-piperidinylcarbamate: LC-MS m/z 599 (M+H)+, 1.99 min (ret time).

Workup

  1. customLC-MS m/z 599 (M+H)+, 1.99 min (ret time)

Sources & evidence

ORD record
ord-75da7882499f476ab491ef79148afe4d
Source dataset
uspto-grants-2012_06
Patent number
US08207176B2

Reaction notes

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