HuagongsheHuagongshe Chemistry Print Report · For research reference only
CBz-D-phenylglycine 4-(1-methylpiperidin-4-yl)piperidinamide → D-Phenylglycine 4-(1-methylpiperidin-4-yl)piperidinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | CBz-D-phenylglycine 4-(1-methylpiperidin-4-yl)piperidinamide | HCID 131722772 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | D-Phenylglycine 4-(1-methylpiperidin-4-yl)piperidinamide | HCID 131722773 | 76% |
Reaction Steps
A vigorously stirred solution of CBz-D-phenylglycine-4-(1-methylpiperidin-4-yl)piperidinamide (1.1 g, 2.45 mmol) in methanol (120 ml), containing Palladium on carbon (200 mg) was treated with hydrogen gas (balloon) at atmospheric pressure overnight. The reaction mixture was filtered through celite and concentrated to yield the title compound as a colourless oil (585 mg, 76%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06420438B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-b9477f48cf734c3b8f1694658a73b8c0 |
| Source note | uspto-grants-2002_07 |