Acetic Acid → 3-(2,3-Dichloro-phenylsulphonylmethyl)-5-methyl-1,2,4-oxadiazole

Participants

Reaction Steps

3.9 g (14.2 mmol) of 3-(2,3-dichloro-phenylthiomethyl)-5-methyl-1,2,4-oxadiazole are introduced into 50 ml of glacial acetic acid and the mixture is treated with 9.8 ml of 30% strength hydrogen peroxide. The mixture is stirred at reflux temperature until the reaction is complete (approximately 2 hours). The entire batch is then introduced into 200 ml of water, and the crude product which has precipitated is separated off and recrystallised from isopropanol. 1.7 g (38.9% of theory) of 3-(2,3-dichloro-phenylsulphonylmethyl)-5-methyl-1,2,4-oxadiazole are obtained.

Provenance & Evidence