HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Phenyl-2,2-dimethyl-1,3-propanediamine → 2-((-3-Amino-2 2-dimethyl-3-phenylpropyl)-amino)-3-methyl-5-(3-methylphenyl)-6-(4-pyridyl)-4(3H)-pyrimidinone Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Phenyl-2,2-dimethyl-1,3-propanediamine | HCID 10261665 | — |
| Reactant | 2-Chloro-3-methyl-6-pyridin-4-yl-5-m-tolyl-3H-pyrimidin-4-one | HCID 16115688 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-((-3-Amino-2 2-dimethyl-3-phenylpropyl)-amino)-3-methyl-5-(3-methylphenyl)-6-(4-pyridyl)-4(3H)-pyrimidinone Hydrochloride | HCID 18767928 | — |
Reaction Steps
A solution of 2-chloro-3-methyl-5-(3-methylphenyl)-6-(4-pyridyl)-4(3H)-pyrimidinone (228 mg, 0.73 mmol) and 3-phenyl-2,2-dimethyl-1,3-propanediamine (178 mg, 1 mmol) (prepared according to:W. Ten Hoeve and H. Wynberg, Synth. Commun. 24 (15), 2215-2221, 1994) in ethanol (4 ml) was stirred at room temperature for 16 h. The solvent was evaporated and the crude product purified by column chromatography on silica geJ. MS (m/z): 454 (M+H)+; C28H31N5O requir. 453.6 (free base).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06420385B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-b9fd88e20a09431db76cc9eb1d3becd6 |
| Source note | uspto-grants-2002_07 |