Sodium Carbonate → HCID 57515703, compound

Participants

Reaction Steps

Aqueous sat. sodium carbonate (2 ml) was added to a solution of 2-chloro-3-methyl-6-(4-pyridyl)-5-(3-trifluoromethylphenyl)-4(3H)-pyrimidinone hydrochloride (730 mg, 2 mmol) and (S)-1-phenyl-1,3-propanediamine (360 mg, 2.4 mmol) in ethanol (10 ml). The mixture was stirred for 4 h at room temperature. It was evaporated and the remainder partitioned between dichloromethane and water. The organic solution was dried and evaporated followed by column chromatography on silica gel (dichloromethane:methanol conc. ammonium hydroxide=93 7:0.7). MS (m/z): 480 (M+H)+; C26H24F3N5O requir. 479.5 (free base).

Provenance & Evidence