HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl L-phenylalaninate hydrochloride → HCID 53816216, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl L-phenylalaninate hydrochloride | HCID 75736 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | beta-Resorcylic acid, 3,5-dichloro- | HCID 3042133 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 53816216 | HCID 53816216 | 62.6% |
Reaction Steps
To a solution of 3,5-dichloro-2,4-dihydroxybenzoic acid (17 g), L-phenylalanine methyl ester hydrochloride (19.8 g), WSC.HCl (17.6 g) and HOBT (12.4 g) in DMF (70 ml) was added dropwise triethylamine (12.8 ml) at room temperature, and the mixture was stirred for 16 hours. Then, the mixture was post-treated in the same manner as in the above Example 1, Step 5) to give the title compound (18.32 g, yield 57%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06420561B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-80de33137abe486b93570a4ef239340a |
| Source note | uspto-grants-2002_07 |