反应详情

The process is performed under the conditions of Example 1, starting with 1.3 g of 2-amino-2-(4-methoxyphenyl)-1-ethanol and 1.46 cm3 of tert-butyl isothiocyanate in 12 cm3 of absolute ethanol for 21 hours at a temperature in the region of 20° C. After concentration of the reaction mass under reduced pressure (5 kPa) at a temperature in the region of 40° C., the residue obtained is taken up in 10 cm3 of water. A crystalline precipitate forms, which is filtered off, washed with 3 times 5 cm3 of diethyl ether and dried under reduced pressure (10 Pa) at a temperature in the region of 40° C. 1.32 g of N-(tert-butyl)-N′-[1-(4-methoxyphenyl)-2-hydroxyethyl]thiourea are obtained in the form of a white solid melting at 127° C.

1. customAfter concentration of the reaction mass under reduced pressure (5 kPa) at a temperature in the region of 40° C., the residue obtained
2. filtrationA crystalline precipitate forms, which is filtered off
3. washwashed with 3 times 5 cm3 of diethyl ether
4. customdried under reduced pressure (10 Pa) at a temperature in the region of 40° C