Hydrochloric Acid → HCID 70130029, compound

Participants

Reaction Conditions

Reaction Steps

The process is performed under the conditions of Example 1, starting with 2.4 g of N-(tert-butyl)-N′-[(1R)-2-hydroxy-1-phenylethyl]thiourea in 24 cm3 of aqueous 6N hydrochloric acid for 1 hour 30 minutes at a temperature in the region of 100° C. After cooling the medium to a temperature in the region of 0° C., the precipitate formed is filtered off and the filter cake is then washed with 7 cm3 of aqueous 6N hydrochloric acid and twice 15 cm3 of diethyl ether. The solid obtained is dried in an oven under reduced pressure (10 Pa) at a temperature in the region of 60° C. 1.6 g of (−)-(4R)-4-phenyl-4,5-dihydro-1,3-thiazol-2-ylamine hydrochloride are obtained in the form of a white solid melting at 260° C. (αd20=−109.6±1.3 at a concentration of 1% in methanol).

Provenance & Evidence