L-Phenylalanine → L-Leucine

Participants

Reaction Steps

A solution of compound (16) (211 mg, 0.64 mmol) and CH2Cl2 (20 mL) was purged with argon gas for 10 minutes. Grubbs Catalyst 1 (1.6 mg, 19.2 μmol) was added and the reaction was heated to reflux and monitored by TLC. The reaction was concentrated under reduced pressure and subjected to flash chromatography (2:1 Hexanes/EtOAc) to afford 187 mg (98%) of (17a) as a separable mixture of two diastereomers (17a, and 17a), both as colorless oils.

Provenance & Evidence