Formamide → 1-Phenylethanol

Participants

Reaction Steps

The operation was conducted in the same manner as in Example 1 but using an N-phenyl-1-formyl-(S)-prolineamide which was an amide compound having an oxo group on a carbon atom at the β-position of the nitrogen atom, as a formamide compound, instead of using the 1-formylpyrrolidine and conducting the reaction for 15 hours. As a result, there was obtained 0.121 g of a 1-phenyl-1-ethanol (yield, 99%). Further, this compound was measured for its optical purity to be 32.5% ee (R).

Provenance & Evidence