関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Stannous Chloride | HCID 24479 | — |
| 反応物 | 5-Nitro-2,1,3-benzothiadiazole | HCID 297897 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 2,1,3-Benzothiadiazol-5-amine | HCID 314313 | 88% |
反応手順
To a solution of 5-nitrobenzo-2,1,3-thiadiazole in a mixture of dioxane (22 mL) and ethanol (22 mL) at RT added solid SnCl2 followed by addition of water (1 mL). The reaction mixture was warmed up to 50° C. and stirred for 10 min, cooled to RT, concentrated and partitioned between ethyl acetate/1N NaOH. The organic layer was washed with 1N NaOH, water, brine, dried over MgSO4 and charcoal. Evaporation of the solvent gave 5-aminobenzo-2,1,3-thiadiazole as a yellow powder (3.0 g, 88%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06420567B1 |
|---|
| 出典データセット | uspto-grants-2002_07 |
|---|
| ORD ID | ord-62aca560783c4d35bac56c04f82023ed |
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| 出典メモ | uspto-grants-2002_07 |
|---|
