HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-Acetyl-tyrosinyl-valinyl-(4-phenoxy)proline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | N-Acetyl-tyrosinyl-valinyl-(4-phenoxy)proline Methyl Ester | HCID 54377655 | — |
| Solvent | Oxolane--water (1/1) | HCID 21881883 | — |
| Product | N-Acetyl-tyrosinyl-valinyl-(4-phenoxy)proline | HCID 54232766 | 49.9% |
Reaction Steps
Lithium hydroxide (57 mg, 1.37 mmol) was added to a solution of N-Acetyl-tyrosinyl-valinyl-(4-phenoxy)proline methyl ester (360 mg, 0.685 mmol) dissolved in 8 ml of tetrahydrofuran/water (1:1) and stirred at room temperature for 1 hour. The mixture was acidified with 10% hydrochloric acid giving a white precipitate that was collected to give 175 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06420522B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-8b9ccbdcb00a430cbdc28721602966d7 |
| Source note | uspto-grants-2002_07 |