HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Peroxide → 1-(2-Hydroxy-2-methylpropoxy)-2,2,6,6-tetramethylpiperidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Peroxide | HCID 784 | — |
| Reactant | tert-Butanol | HCID 6386 | — |
| Reactant | Sodium Sulfite | HCID 24437 | — |
| Reactant | 1-Hydroxy-2,2,6,6-tetramethyl-4-oxopiperidine | HCID 98642 | — |
| Product | 1-(2-Hydroxy-2-methylpropoxy)-2,2,6,6-tetramethylpiperidin-4-one | HCID 21885057 | — |
Reaction Steps
Aqueous hydrogen peroxide is added to a mixture of 1-oxyl-2,2,6,6-tetramethylpiperidin-4-one and ferrous chloride in tert-butyl alcohol at 30-60° C. Excess peroxide is decomposed with aqueous sodium sulfite. The organic layer is concentrated and the residue is purified by flash chromatography to afford the desired 1-(2-hydroxy-2-methylpropoxy)-2,2,6,6-tetramethylpiperidin-4-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06420463B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-b3dad4b3cbf34da1a83edc5497b0d547 |
| Source note | uspto-grants-2002_07 |