HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → N-(Toluene-4-sulfonyl)-L-prolyl-L-asparagine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl L-asparaginate--hydrogen chloride (1/1) | HCID 16218498 | — |
| Reactant | N-tosyl-(s)-proline monohydrate | HCID 69463844 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(Toluene-4-sulfonyl)-L-prolyl-L-asparagine | HCID 9951963 | — |
Reaction Steps
N-(Toluene4-sulfonyl)-L-proline hydrate was coupled to L-asparagine tert-butyl ester hydrochloride using the procedure described in Method 3. The title compound was prepared, via cleavage of the tert-butyl ester using trifluoroacetic acid in CH2Cl2, to provide a solid, mp=178-180° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06423688B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-75c22a6a627e494d820b465320793dc8 |
| Source note | uspto-grants-2002_07 |