[Methyl-(toluene-4-sulfonyl)-amino]-acetic acid → N-(toluene-4-sulfonyl)sarcosyl-beta-(4-pyridyl)alanine

HRID 2230025Notes

Reaction equation

HRID 2230025 reaction equation
[C:1]1([CH3:16])[CH:6]=[CH:5][C:4]([S:7]([N:10]([CH2:12][C:13]([OH:15])=O)[CH3:11])(=[O:9])=[O:8])=[CH:3][CH:2]=1.Cl.Cl.C[O:20][C:21](=[O:31])[C@H:22]([CH2:24][C:25]1[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=1)[NH2:23]>>[C:1]1([CH3:16])[CH:2]=[CH:3][C:4]([S:7]([N:10]([CH2:12][C:13]([NH:23][C@H:22]([C:21]([OH:31])=[O:20])[CH2:24][C:25]2[CH:26]=[CH:27][N:28]=[CH:29][CH:30]=2)=[O:15])[CH3:11])(=[O:8])=[O:9])=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 802555[Methyl-(toluene-4-sulfonyl)-amino]-acetic acidHCID 69462863methyl (2S)-2-amino-3-pyridin-4-ylpropanoate;dihydrochloride

Product 1

HCID 20582825N-(toluene-4-sulfonyl)sarcosyl-beta-(4-pyridyl)alanine

Procedure

N-(Toluene-4-sulfonyl)sarcosine was coupled to 3-(4-pyridyl)alanine methyl ester dihydrochloride using the procedure described in Method 3 to give N-(toluene-4-sulfonyl)sarcosyl-β-(4-pyridyl)alanine.

Sources & evidence

ORD record
ord-b2ddcb70137d4a6982b00c997e7d1e35
Source dataset
uspto-grants-2002_07
Patent number
US06423688B1

Reaction notes

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