1,3-Propanediamine, N1,N1,N3-trimethyl- → 3-{8-(2,6-difluorophenyl)-2-[[3-(dimethylamino)propyl](methyl)amino]-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl}-4-methyl-N-1,3-thiazol-2-ylbenzamide

Participants

Reaction Steps

The title compound was prepared from 3-[8-(2,6-difluorophenyl)-2-(methylsulfinyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methyl-N-1,3-thiazol-2-ylbenzamide and N,N,N′-trimethyl-1,3-propanediamine by following the procedures in Example 79c. LC-MS m/z 590 (M+H)+; 1H-NMR (MeOD) 1.70 (m, 2H), 2.04 (m, 2H), 2.20 (s, 6H), 2.36 (s, 3H), 2.89-3.21 (m, 3H), 3.36-3.70 (m, 2 H), 6.36 (d, J=8.4 Hz, 1H), 7.16 (m, 1H), 7.27 (m, 2H), 7.50 (m, 2H), 7.59 (m, 2 H), 8.01 (s, 1H), 8.13 (m, 1H).

Provenance & Evidence