(3-Acetamidophenyl)boronic acid → N-[3-(8-(2,4-difluorophenyl)-2-{[2-hydroxy-1-(hydroxymethyl)ethyl]amino}-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl)phenyl]acetamide

Participants

Role	Name	HCID	Charge
Reactant	(3-Acetamidophenyl)boronic acid	HCID 157274	—
Reactant	4-chloro-8-(2,4-difluorophenyl)-2-{[2-hydroxy-1-(hydroxymethyl)ethyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one	HCID 11951516	—
Product	N-[3-(8-(2,4-difluorophenyl)-2-{[2-hydroxy-1-(hydroxymethyl)ethyl]amino}-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl)phenyl]acetamide	HCID 59212692	—

Reaction Steps

The title compound was prepared by following the procedure in example 96d from 4-chloro-8-(2,4-difluorophenyl)-2-{[2-hydroxy-1-(hydroxymethyl)ethyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one and [3-(acetylamino)phenyl]boronic acid: LC-MS m/z 482 (M+H)+, retention 2.69 min.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08207176B2
Source dataset	uspto-grants-2012_06
ORD ID	ord-ad29b24285634637a9550f3578442293
Source note	uspto-grants-2012_06