N,N-Dimethylethylenediamine → 3-(8-(2,6-difluorophenyl)-2-{[2-(dimethylamino)ethyl]amino}-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl)-4-methyl-N-1,3-thiazol-2-ylbenzamide

Participants

Reaction Steps

The title compound was prepared from 3-[8-(2,6-difluorophenyl)-2-(methylsulfinyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methyl-N-1,3-thiazol-2-ylbenzamide and N,N-dimethyl-1,2-ethanediamine by following the procedures in Example 79c. LC-MS m/z 562 (M+H)+; 1H-NMR (MeOD) 2.15 (m, 6H), 2.36 (m, 4H), 2.65 (m, 1H), 3.27 (m, 2H), 6.38 (d, J=8.4 Hz, 1H), 7.17 (m, 1H), 7.25 (m, 2H), 7.49 (m, 2H), 7.59 (m, 2H), 8.00 (s, 1H), 8.11 (d, J=8.0 Hz, 1H).

Provenance & Evidence