Tetrahydrofuran → HCID 86758373, compound

Participants

Reaction Steps

The reaction mixture of 5-nitro-2-furoic acid (157 mg, 1.0 mmol), 1-(3-hydroxypropyl)-2-methyl-5-nitroimidazole (184 mg, 1.0 mmol), EDCI (260 mg, 1.3 mmol), DMAP (10 mg, 0.1 mmol) and THF (5 ml) will be stirred at room temperature for 10 h. Evaporation of THF gives a residue which will be dissolved in ethyl acetate. The organic layer of ethyl acetate will be washed with H2O, 5% Na2CO3, H2O and brine, and then dried over MgSO4. The solvent will be removed under vacuum. The resulting solid will be recrystallized from C2H5OH to give 2-methyl-5-nitro-1H-imidazole-1-propyl 5-nitro-2-furoate.

Provenance & Evidence