Metronidazole → HCID 70170430, compound

Participants

Reaction Steps

The reaction mixture of 2-Phenyl-4-quinolinecarboxylic acid (274 mg, 1.1 mmol), metronidazole (171 mg, 1.0 mmol), EDCI (228 mg, 1.2 mmol), DMAP (20 mg, 0.2 mmol) and THF (5 ml) was stirred at room temperature for 10 h. THF was then removed under reduced pressure. The residue was dissolved in ethyl acetate. The organic layer was washed with H2O, 5% Na2CO3, H2O, and brine, and then dried over MgSO4. The solvent was removed under vacuum. The resulting solid was recrystallized from C2H5OH to give 305 mg (76.62%) 2-methyl-5-nitro-1H-imidazole-1-ethyl 2-phenyl-4-quinolinecarboxylate. m.p.: 122-124° C.

Provenance & Evidence