Chromocarb → HCID 70169091, compound

Participants

Reaction Steps

The reaction mixture of chromone-2-carboxylic acid (190 mg, 1.0 mmol) and thionyl chloride (2 ml) was refluxed for 2 h. The excessive thionyl chloride was evaporated under vacuum. The residue was dissolved in 5 ml of dichloromethane. To this solution, metronidazole (162 mg, 0.95 mmol) was added. After the mixture was stirred at room temperature overnight some solid came out. The solid was filtered and was recrystallized from C2H5OH-CH3OH to give 102 mg 2-methyl-5-nitro-1H-imidazole-1-ethyl 4-oxo-4H-1-benzopyran-2-carboxylate. m.p.: 210-212° (dec.).

Provenance & Evidence