Metronidazole → HCID 131723409, compound

Participants

Reaction Steps

The reaction mixture of (+)-2-(2,4,5,6-tetranitro-9-fluorenylideneaminooxy)proprionic acid (223 mg, 0.5 mmol), metronidazole (86 mg, 0.5 mmol), EDCI (133 mg, 0.7 mmol), DMAP (10 mg, 0.1 mmol) and THF (5 ml) was stirred at room temperature for 6 h. THF was then removed under reduced pressure. The residue was dissolved in dichloromethane (50 ml). The organic layer was washed with H2O, 5% Na2CO3, H2O, and brine, and then dried over MgSO4. The solvent was removed under vacuum. The resulting liquid was separated by column chromatography to give 160 mg 2-methyl-5-nitro-1H-imidazole-1-ethyl (+)-2-(2,4,5,7-tetranitro-9-fluorenylideneaminooxy)propionate.

Provenance & Evidence