HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2230089Generated: October 27, 2026
Benzene, 1-iodo-4-(trifluoromethyl)- → 4-(4-Trifluoromethylphenyl)-thiomorpholin-3-one
https://huagongshe.com/reaction/2230089
Participants
| Role | Name | HCID | Charge |
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| Reactant | Benzene, 1-iodo-4-(trifluoromethyl)- | HCID 67993 | — |
| Reactant | 1,4-Tetrahydrothiazine-3-one | HCID 88402 | — |
| Catalyst | Copper | HCID 23978 | — |
| Product | 4-(4-Trifluoromethylphenyl)-thiomorpholin-3-one | HCID 12083010 | 23.3% |
Reaction Steps
A mixture of thiomorpholin-3-one (500 mg, 4.27 mmol), 4-trifluoromethyl-1-iodobenzene (1.25 mL, 8.5 mmol) and copper metal (814 mg, 12.8 mmol) was heated in a sealed glass tube at 185-200° C. for 18 hours. The residue was then purified by flash chromatography to give 260 mg of the title product as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06423708B1 |
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| Source dataset | uspto-grants-2002_07 |
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| ORD ID | ord-4d7c2222737c4a239efa6c11d54572ea |
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| Source note | uspto-grants-2002_07 |
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