4-Pyridinemethanamine → 6,7-Dimethoxy-4-{4-[2-nitro-1-(4-pyridylmethylamino)vinyl]-1-piperazinyl}quinazoline

Participants

Reaction Conditions

Reaction Steps

To a pyridine solution (10 mL) of Compound 58 produced in Example 58 (730 mg, 1.87 mmol), 4-aminomethylpyridine (0.57 mL, 5.61 mmol) was added, followed by stirring in argon atmosphere under heating at 80° C. for 5 hours. After the reaction solution was allowed to stand for cooling, the solvent was evaporated, and the resulting residue was purified by silica gel column chromatography to give the target compound (130 mg, 0.29 mmol).

Provenance & Evidence