2-Naphthalenesulfonyl chloride → Naphthalene-2-sulfonic acid [2-bromo-5-(4-methylpiperazin-1-yl)phenyl]amide

HRID 2230127Notes

Reaction equation

HRID 2230127 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11](Cl)(=[O:13])=[O:12].[Br:15][C:16]1[CH:21]=[CH:20][C:19]([N:22]2[CH2:27][CH2:26][N:25]([CH3:28])[CH2:24][CH2:23]2)=[CH:18][C:17]=1[NH2:29]>>[Br:15][C:16]1[CH:21]=[CH:20][C:19]([N:22]2[CH2:23][CH2:24][N:25]([CH3:28])[CH2:26][CH2:27]2)=[CH:18][C:17]=1[NH:29][S:11]([C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:1]=1)(=[O:13])=[O:12]

Participants

3

Reactant 2

HCID 71252-Naphthalenesulfonyl chlorideHCID 181800752-Bromo-5-(4-methylpiperazin-1-yl)phenylamine

Product 1

HCID 18180108Naphthalene-2-sulfonic acid [2-bromo-5-(4-methylpiperazin-1-yl)phenyl]amide

Procedure

The title compound (E118) was prepared from naphthalene-2-sulfonyl chloride (100 mg, 0.44 mmol) and 2-bromo-5-(4-methylpiperazin-1-yl)phenylamine (D27) (120 mg, 0.44 mmol) using the method of Example 1 (85 mg, 35%) MH+=460/462.

Sources & evidence

ORD record
ord-0e0c978e221540bbb0373e924fe7a597
Source dataset
uspto-grants-2002_07
Patent number
US06423717B1

Reaction notes

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