5-Chloro-3-methylbenzo(b)thiophene-2-sulfonyl chloride → HCID 18180068, compound

HRID 2230134Notes

Reaction equation

HRID 2230134 reaction equation
[NH2:1][C:2]1[C:7]([CH2:8][CH2:9][OH:10])=[C:6]([N:11]2[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]2)[C:5]([O:18][CH3:19])=[CH:4][CH:3]=1.[Cl:20][C:21]1[CH:34]=[CH:33][C:24]2[S:25][C:26]([S:29](Cl)(=[O:31])=[O:30])=[C:27]([CH3:28])[C:23]=2[CH:22]=1>>[OH:10][CH2:9][CH2:8][C:7]1[C:6]([N:11]2[CH2:12][CH2:13][N:14]([CH3:17])[CH2:15][CH2:16]2)=[C:5]([O:18][CH3:19])[CH:4]=[CH:3][C:2]=1[NH:1][S:29]([C:26]1[S:25][C:24]2[CH:33]=[CH:34][C:21]([Cl:20])=[CH:22][C:23]=2[C:27]=1[CH3:28])(=[O:31])=[O:30]

Participants

3

Reactant 2

HCID 27357565-Chloro-3-methylbenzo(b)thiophene-2-sulfonyl chlorideHCID 18180172HCID 18180172, compound

Product 1

HCID 18180068HCID 18180068, compound

Procedure

The title compound (E126) was prepared from 2-[6-amino-3-methoxy-2-(4-methylpiperazin-1-yl)phenyl]ethanol (D32) (74 mg, 0.28 mmol) and 5-chloro-3-methylbenzo[b]thiophene-2-sulfonyl chloride (78 mg, 0.28 mmol) using the method of Example 1 (18 mg, 13%). MH+=510.

Sources & evidence

ORD record
ord-19e5ec8b70f54dad8e7a24a7952855d7
Source dataset
uspto-grants-2002_07
Patent number
US06423717B1

Reaction notes

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