Hydrochloric Acid → HCID 12050311, compound

Participants

Reaction Steps

To a stirred suspension of 4-(2-keto-1-benzimidazolinyl)piperidine (500 mg, 2.3 mmol) in 2N HCl(1.15 ml, 2.3 mmol) and water(0.5 ml) was added cyclohexanone(0.24 ml, 2.3 mmol) at 0° C. To this mixture was added a solution of KCN(156 mg, 2.4 mmol) in water(0.3 ml) all at once at room temperature. After 17 h stirring at room temperature, the precipitated white solid was collected by filtration, washed with water, and dried under vacuum at 50° C. for 1 h to afford 605 mg of white powder. As this included small amount of starting material amine, this was purified by column chromatography(silica gel: 130 g, CH2Cl2MeOH:30/1 to 20/1) to give 293 mg(39.3%) of white powder, mp199-201° C.

Provenance & Evidence