HCID 12050338, compound → HCID 12050328, compound

HRID 2230171Notes

Reaction equation

HRID 2230171 reaction equation
[O:1]=[C:2]1[N:6]([CH:7]2[CH2:12][CH2:11][N:10]([C:13]3([C:17]#N)[CH2:16][CH2:15][CH2:14]3)[CH2:9][CH2:8]2)[C:5]2[CH:19]=[CH:20][CH:21]=[CH:22][C:4]=2[NH:3]1.[C:23]1([Mg]Br)[CH:28]=[CH:27]C=[CH:25][CH:24]=1>>[C:17]1([C:13]2([N:10]3[CH2:9][CH2:8][CH:7]([N:6]4[C:5]5[CH:19]=[CH:20][CH:21]=[CH:22][C:4]=5[NH:3][C:2]4=[O:1])[CH2:12][CH2:11]3)[CH2:16][CH2:15][CH2:14]2)[CH:27]=[CH:28][CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 12050338HCID 12050338, compoundHCID 178418255HCID 178418255, compound

Product 1

HCID 12050328HCID 12050328, compoundYield 48%

Procedure

This was prepared according to the procedure described in example 1 using 1-[4-(2-oxo-2,3-dihydro-1H-1,3-benzimidazol-1-yl)piperidino]-1-cyclobutanecarbonitrile and phenylmagnesium bromide. Yield was 48%.

Workup

  1. customThis was prepared

Sources & evidence

ORD record
ord-c22f611b5d6a49759ed59aff40e4c7d5
Source dataset
uspto-grants-2002_07
Patent number
US06423725B1

Reaction notes

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