Dimethylformamide → HCID 18465470, compound

Participants

Reaction Steps

A mixture of 1-(2-aminoethyl)-3-[1-(1-phenylcycloheptyl)-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one dihydrochloride (37.81 mg, 0.0751 mmol, this was prepared according to the procedure of Preparation 18 and Example 64). 2-bromopyridine (14 mg, 0.0901 mol), K2CO3 (36 mg, 0.263 mmol), and DMF (1 ml) was stirred at 60° C. for 4 h. The mixture was diluted with CH2Cl2, washed with water, dried (Na2SO4), filtered, and concentrated. The residue was purified by preparative TLC (acetone/hexane:2/3) to give 3.3 mg (8.6%) of colorless oil.

Provenance & Evidence