4-(Methylthio)phenylboronic acid → HCID 18465484, compound

HRID 2230236Notes

Reaction equation

HRID 2230236 reaction equation
[SH:1][CH:2]([CH2:33][CH:34]([CH3:36])[CH3:35])[C:3]([NH:5][C:6]1([C:11]([NH:13][CH:14]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]3[CH:30]=[CH:29][C:28](SC)=[CH:27][CH:26]=3)=[CH:21][CH:20]=2)[C:15]([OH:17])=[O:16])=[O:12])[CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:4].CS[C:39]1[CH:44]=[CH:43][C:42](B(O)O)=[CH:41][CH:40]=1>>[SH:1][CH:2]([CH2:33][CH:34]([CH3:36])[CH3:35])[C:3]([NH:5][C:6]1([C:11]([NH:13][CH:14]([CH2:18][C:19]2[CH:20]=[CH:21][C:22]([C:25]3[CH:26]=[CH:27][C:28]([C:41]4[C:42]5[C:43](=[CH:3][CH:2]=[CH:33][CH:34]=5)[CH:44]=[CH:39][CH:40]=4)=[CH:29][CH:30]=3)=[CH:23][CH:24]=2)[C:15]([OH:17])=[O:16])=[O:12])[CH2:7][CH2:8][CH2:9][CH2:10]1)=[O:4]

Participants

3

Reactant 2

HCID 27339594-(Methylthio)phenylboronic acidHCID 22997551HCID 22997551, compound

Product 1

HCID 18465484HCID 18465484, compound

Procedure

2-{[1-(2-mercapto4-methyl-pentanoylamino)-cyclopentanecarbonyl]-amino}-3-(4′-methylthio-biphenyl-4-yl)-propionic acid (from 4-methylthiophenyl-boronic acid; mp 187-189° C.

Sources & evidence

ORD record
ord-d51edd5fe44a4d88abe636a32193624c
Source dataset
uspto-grants-2002_07
Patent number
US06423727B1

Reaction notes

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