HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → 3-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)propan-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 2-(3-(Boc-amino)-propyl)-5,6,7,8-tetrahydro-1,8-naphthyridine | HCID 11231632 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)propan-1-amine | HCID 9877599 | — |
Reaction Steps
The title compound was prepared by treating the Boc derivative 1-5 with either HCI gas in ethyl acetate as described in U.S. Pat. No. 5,952,341 and WO 99/31061, or with trifluoroacetic acid in methylene chloride, or aqueous sulfuric acid; m.p. 66.0-68.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06423845B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-56bab09272524c0399e8165db53e3427 |
| Source note | uspto-grants-2002_07 |