Sulfuric Acid → HCID 11323027, compound

HRID 2230245Notes

Reaction equation

HRID 2230245 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]1[O:16][CH:15]=[N:14][C:13]=1[C:17]([O:19]CC)=[O:18].[OH-].[K+].S(=O)(=O)(O)O>O>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([N+:9]([O-:11])=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]1[O:16][CH:15]=[N:14][C:13]=1[C:17]([OH:19])=[O:18]

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 14797Potassium HydroxideHCID 9882509HCID 9882509, compound

Product 1

HCID 11323027HCID 11323027, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 780 ml of water were added 15.6 g (0.053 mol) of the 5-(2-methoxy-4-nitrophenyl)-4-carboethoxyoxazole prepared in (1) above and 24.0 g (0.107 mol) of a 25% aqueous solution of potassium hydroxide, and the mixture was allowed to react at 80° C. for 1 hour. After cooling to room temperature, the reaction mixture was adjusted to pH 2 with 30% sulfuric acid. The crystals thus precipitated were collected by filtration to obtain the title compound as a wet cake weighing 41.3 g and having a water content of 68%. That is, the yield of the compound was 13.2 g (0.05 mol, 93.9% based on the 5-(2-methoxy-4-nitrophenyl)-4-carboethoxyoxazole).

Workup

  1. customto react at 80° C. for 1 hour
  2. customThe crystals thus precipitated
  3. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-dfaf0f98cca04c4db2f5d789c973dc67
Source dataset
uspto-grants-2002_07
Patent number
US06423849B1

Reaction notes

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