HCID 10496506, compound → HCID 18466198, compound

HRID 2230259Notes

Reaction equation

HRID 2230259 reaction equation
[CH2:1]([O:3][C:4](=[O:24])[C:5](=[CH:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][C:13]=1[O:22][CH3:23])[C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH3:2]>C(O)C.[Ni]>[CH2:9]([O:8][C:6](=[O:7])[CH:5]([CH2:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=[CH:14][C:13]=1[O:22][CH3:23])[C:4]([O:3][CH2:1][CH3:2])=[O:24])[CH3:10]

Participants

4

Reactant 1

HCID 10496506HCID 10496506, compound

Product 1

HCID 18466198HCID 18466198, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

After being solubilised in ethanol (510 ml), the unsaturated compound obtained in Step A (10 g, 3.05.10−2 mol) is hydrogenated in the presence of Raney nickel at ambient temperature with vigorous stirring. The reaction is monitored by TLC and GPC after 4 hours' hydrogenation. After it has been established that the starting material has disappeared, the catalyst is filtered off over Celite and the ethanol is evaporated off under reduced pressure. The title product is obtained in the form of a colourless oil.

Workup

  1. filtrationthe catalyst is filtered off over Celite
  2. customthe ethanol is evaporated off under reduced pressure

Sources & evidence

ORD record
ord-2d02493cfc49482caf38fdc513da1984
Source dataset
uspto-grants-2002_07
Patent number
US06423870B1

Reaction notes

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