反应详情

The ester obtained in Step C (1.9 g, 7.91.10−3 mol) is heated at reflux in the presence of potassium hydroxide (2.34 g, 4.17.10−2 mol, 5.3 eq.), water (16 ml) and methanol (16 ml) for one night. After evaporating off the solvent, the residue is taken up in water and extracted twice with ether. The basic aqueous phase is acidified using concentrated HCl in the cold state. The acid is extracted with ethyl acetate and dried over MgSO4. After evaporating off the solvent under reduced pressure, the title compound is obtained in the form of a yellow solid.

1. customAfter evaporating off the solvent
2. extractionextracted twice with ether
3. extractionThe acid is extracted with ethyl acetate
4. dry with materialdried over MgSO4
5. customAfter evaporating off the solvent under reduced pressure