Sodium borohydride → HCID 10821610, compound

HRID 2230268Notes

Reaction equation

HRID 2230268 reaction equation
[BH4-].[Na+].[C:3]1(=[CH:15][C:16]#[N:17])[C:13]2=[C:14]3[C:9](=[CH:10][CH:11]=[CH:12]2)[CH:8]=[CH:7][CH:6]=[C:5]3[CH2:4]1>CO.Cl[Pd]Cl>[CH:3]1([CH2:15][C:16]#[N:17])[C:13]2=[C:14]3[C:9](=[CH:10][CH:11]=[CH:12]2)[CH:8]=[CH:7][CH:6]=[C:5]3[CH2:4]1

Participants

5

Reactant 2

HCID 4311764Sodium borohydrideHCID 69848100HCID 69848100, compound

Product 1

HCID 10821610HCID 10821610, compound

Reagents, catalysts & solvents 2

HCID 24290Palladium ChlorideCatalystHCID 887MethanolSolvent2×

Procedure

The catalyst is prepared starting from 55 mg of PdCl2 in 5 ml of methanol treated with 25 mg of sodium borohydride. After 15 minutes' stirring, the compound obtained in Step A (1 g, 5.23.10−3 mol), diluted with methanol (15 ml), is incorporated. The mixture is purged with argon and placed under hydrogen. After 3 days' hydrogenation, the reaction mixture is filtered over Celite, rinsed and then evaporated under reduced pressure. The title product is isolated in the form of a light brown oil.

Workup

  1. customThe catalyst is prepared
  2. customThe mixture is purged with argon
  3. waitAfter 3 days' hydrogenation
  4. filtrationthe reaction mixture is filtered over Celite
  5. washrinsed
  6. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-093f7d6e7ef945e89e87a5ba4ae8000a
Source dataset
uspto-grants-2002_07
Patent number
US06423870B1

Reaction notes

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