4-Hydroxymethylpyridine → HCID 70058792, compound

HRID 2230279Notes

Reaction equation

[C:1]([O:5][C:6](=[O:34])[C@@H:7]([NH:16][C:17]([O:19][CH2:20][CH:21]1[C:33]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[C:27]2[C:22]1=[CH:23][CH:24]=[CH:25][CH:26]=2)=[O:18])[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[N:35]1[CH:40]=[CH:39][C:38]([CH2:41]O)=[CH:37][CH:36]=1>>[C:1]([O:5][C:6](=[O:34])[C@@H:7]([NH:16][C:17]([O:19][CH2:20][CH:21]1[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:27]=2[C:28]2[C:33]1=[CH:32][CH:31]=[CH:30][CH:29]=2)=[O:18])[CH2:8][C:9]1[CH:10]=[CH:11][C:12]([O:15][CH2:41][C:38]2[CH:39]=[CH:40][N:35]=[CH:36][CH:37]=2)=[CH:13][CH:14]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 114724-Hydroxymethylpyridine

HCID 15295906HCID 15295906, compound

Product 1

HCID 70058792HCID 70058792, compound

Procedure

In a manner similar to that described in Example H, the product from Example G (0.5 g, 1.08 mmol) and 4-pyridylcarbinol (0.12 mL, 1.26 mmol) were converted to the title compound.

Sources & evidence

ORD record: ord-b49ed2e603c7487e96ecde46c5074cd0
Source dataset: uspto-grants-2002_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06423689B1

Reaction notes

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