HCID 15295906, compound → HCID 70061022, compound

HRID 2230281Notes

Reaction equation

HRID 2230281 reaction equation
[C:1]([O:5][C:6](=[O:34])[C@@H:7]([NH:16][C:17]([O:19][CH2:20][CH:21]1[C:33]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[C:27]2[C:22]1=[CH:23][CH:24]=[CH:25][CH:26]=2)=[O:18])[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].C([CH:42](O)[C:43]1[CH:48]=[CH:47][CH:46]=[C:45]([NH2:49])[CH:44]=1)(OC(C)(C)C)=O>>[C:1]([O:5][C:6](=[O:34])[C@@H:7]([NH:16][C:17]([O:19][CH2:20][CH:21]1[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][C:27]=2[C:28]2[C:33]1=[CH:32][CH:31]=[CH:30][CH:29]=2)=[O:18])[CH2:8][C:9]1[CH:10]=[CH:11][C:12]([O:15][CH2:42][C:43]2[CH:48]=[CH:47][CH:46]=[C:45]([NH:49][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:34])[CH:44]=2)=[CH:13][CH:14]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 15295906HCID 15295906, compoundHCID 57366053HCID 57366053, compound

Product 1

HCID 70061022HCID 70061022, compoundYield 111.4%

Procedure

In a manner similar to that described in Example H, the product from Example G (0.50 g, 1.08 mmol) and BOC-3-aminobenzylalcohol (0.24 g, 1.08 mmol) were converted to the title compound (0.40 g, 60%).

Sources & evidence

ORD record
ord-aa2133014b434734a21e4cb382283e31
Source dataset
uspto-grants-2002_07
Patent number
US06423689B1

Reaction notes

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