HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-Butylamine → HCID 53835888, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-Butylamine | HCID 6385 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | N-(tert-Butoxycarbonyl)-4-nitro-L-phenylalanine | HCID 7021882 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 53835888 | HCID 53835888 | 966.9% |
Reaction Steps
A reaction mixture of BOC-L-4-nitrophenylalanine (4.65 g, 1.5 mmol), tert-butylamine (2.19 g, 30 mmol), DMF (10 mL), HBTU (5.69 g, 15 mmol), and diisopropylethylamine (2.48 g, 22 mmol) was stirred for 2 hours. After the reaction was finished, the reaction mixture was added EtOAc (75 mL), and the EtOAc solution was washed with NaHCO3 (100 mL, 4 times), dried over NaHCO3, and concentrated to dryness. The crude reaction mixture was further purified by column chromatography (SiO2, EtOAc/hexane 1:1) to yield the title compound (5.3 g), mp=158-159° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06423689B1 |
| Source dataset | uspto-grants-2002_07 |
| ORD ID | ord-a3e6442f77834e1085dd6b51dbb9ff8c |
| Source note | uspto-grants-2002_07 |