Methanol → HCID 70061470, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of tyrosine (1.83 g, 10 mmol) and CuSO4 (0.81 g, 5 mmol) in 10 mL of 2N NaOH and 5 mL H2O was heated to 60° C. and cooled to room temperature. The reaction mixture was treated with MeOH (35 mL) and 2N NaOH (1.5 mL) followed by α-bromo-p-xylene. The resulting mixture was stirred at 25° C. for 2 hours and filtered. The solid obtained was washed with a 17.5:5 H2O/MeOH solution followed by MeOH. The solid was triturated with 1N HCl (3×10 mL), H2O (2×5 mL), 1.5N NH4OH solution (3×10 mL), and H2O (2×5 mL). The solid obtained was dried overnight under vacuum to give the title compound as a solid (1.99 g, 70%).

Provenance & Evidence