2(S)-[(4-methyl-piperazine-1-carbonyl)-amino]-4-methyl-pentanoic acid → 3-(4-Benzyloxy-phenyl)-2-{4-methyl-2-[(4-methyl-piperazine-1-carbonyl)-amino]-pentanoylamino}-propionic acid tert-butyl ester

Participants

Reaction Steps

A solution of the product from Example AF (2(S)-[(4-methyl-piperazine-1-carbonyl)-amino]-4-methyl-pentanoic acid) (0.25 g, 1.03 mmol) and the product from Example A ((S)-2-amino-3-(4-benzyloxy-phenyl)-propionic acid tert-butyl ester) (0.35 g, 1.03 mmol) were coupled according to the procedure described in Example AH. The reaction mixture was purified by chromatography (silica gel, gradient elution 1:1 EtOAc/heptane; 9:1 EtOAc/EtOH; 9:1:0.1 EtOAc/EtOH/NH4OH) to give the title compound as a white foam (0.35 g, 60%).

Provenance & Evidence