3-Pyridinemethanol → HCID 70060615, compound

Participants

Reaction Steps

A solution of the product from Example 24 (0.3 g, 0.63 mmol), 3-pyridylmethanol (0.061 mL, 0.63 mmol) and triphenylphosphine (0.165 g, 0.63 mmol) in 10 mL of tetrahydrofuran at 0° C. was treated with diethylazodicarboxylate (0.11 g, 0.63 mmol). The reaction mixture was warmed to room temperature and stirred for 4 hours. The reaction mixture was concentrated, and the residue was taken up in EtOAc and washed with sat. aqueous NaHCO3 and brine. The organic phase was dried with Na2SO4, filtered, and concentrated. The residue was purified by HPLC to give the title compound (0.047 g).

Provenance & Evidence