4-Methyloxybenzyl chloride → HCID 70060150, compound

HRID 2230315Notes

Reaction equation

HRID 2230315 reaction equation
[C:1]([O:5][C:6](=[O:34])[CH:7]([NH:16][C:17](=[O:33])[CH:18]([NH:23][C:24]([N:26]1[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1)=[O:25])[CH2:19][CH:20]([CH3:22])[CH3:21])[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:35][O:36][C:37]1[CH:44]=[CH:43][C:40]([CH2:41]Cl)=[CH:39][CH:38]=1>>[C:1]([O:5][C:6](=[O:34])[CH:7]([NH:16][C:17](=[O:33])[CH:18]([NH:23][C:24]([N:26]1[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1)=[O:25])[CH2:19][CH:20]([CH3:22])[CH3:21])[CH2:8][C:9]1[CH:10]=[CH:11][C:12]([O:15][CH2:41][C:40]2[CH:43]=[CH:44][C:37]([O:36][CH3:35])=[CH:38][CH:39]=2)=[CH:13][CH:14]=1)([CH3:3])([CH3:4])[CH3:2]

Participants

3

Reactant 2

HCID 699934-Methyloxybenzyl chlorideHCID 70060999HCID 70060999, compound

Product 1

HCID 70060150HCID 70060150, compoundYield 135.9%

Procedure

In a manner similar to the procedure described in Example 27, the product from Example 24 (0.2 g, 0.42 mmol) and 4-methoxybenzyl chloride (75 mg, 0.42 mmol) were converted to the title compound (0.34 g).

Sources & evidence

ORD record
ord-a70b5783c39b4b2f85ebf9fbfb082ae8
Source dataset
uspto-grants-2002_07
Patent number
US06423689B1

Reaction notes

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