HRID2230318

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2734882

4-Isopropylbenzenesulfonyl chloride

C9H11ClO2S

结构：CC(C)CC(N)C(=O)NC(Cc1ccc(OCc2ccccc2)cc1)C(=O)OC(C)(C)C

HCID54081729

未命名化合物

PRODUCTS

生成物

结构：CC(C)C[C@H](NS(=O)(=O)c1ccc(C(C)C)cc1)C(=O)N[C@@H](Cc1ccc(OCc2ccccc2)cc1)C(=O)OC(C)(C)C

HCID70061056

未命名化合物

收率 71%

PROCEDURE

实验过程

Using a procedure similar to that described in Example 36, the product from Example AI ([S-(R*,R*)]-2-{2-amino-4-methyl-pentanoylamino}-3-(4-benzyloxy-phenyl)-propionic acid tert-butyl ester) (0.20 g, 0.45 mmol) and 4-isopropylphenylsulfonyl chloride (0.10 g, 0.45 mmol) were coupled to give the title compound as a white solid (0.20 g, 71%), mp=147-148° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ef8b567bb3cc4fc291fff7d7d96a7410
来源数据集: uspto-grants-2002_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06423689B1
来源说明: uspto-grants-2002_07

反应 SMILES

[C:1]([O:5][C:6](=[O:32])[CH:7]([NH:23][C:24](=[O:31])[CH:25]([NH2:30])[CH2:26][CH:27]([CH3:29])[CH3:28])[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:11][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[CH:33]([C:36]1[CH:41]=[CH:40][C:39]([S:42](Cl)(=[O:44])=[O:43])=[CH:38][CH:37]=1)([CH3:35])[CH3:34]>>[C:1]([O:5][C:6](=[O:32])[C@@H:7]([NH:23][C:24](=[O:31])[C@@H:25]([NH:30][S:42]([C:39]1[CH:40]=[CH:41][C:36]([CH:33]([CH3:35])[CH3:34])=[CH:37][CH:38]=1)(=[O:44])=[O:43])[CH2:26][CH:27]([CH3:28])[CH3:29])[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:11][CH:10]=1)([CH3:3])([CH3:2])[CH3:4]