HCID 77768281, compound → HCID 77767970, compound

Participants

Reaction Steps

To a solution of the product from Example 134 (0.187 g, 0.33 mmol) in 16 mL of 1:1 THF/methanol mixture was added 20% Pd/C (0.1 g). The resulting solution was hydrogenated for 20.5 hours at 20 psi. The crude mixture was evaporated to dryness and was purified by chromatography (silica gel, 30% ethyl acetate/hexane). It was further purified by crystallizing from petroleum ether and toluene to give the title compound (0.12 g, 65%) as a white solid, mp 155-156° C. Anal. Calc'd for C34H50N4O3: C, 72.56; H, 8.95; N, 9.95. Found: C, 72.2; H, 9.03; N, 9.80

Provenance & Evidence