Cyclopropylamine → HCID 178505593, compound

HRID 2230355Notes

Reaction equation

HRID 2230355 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[C:9]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)=[N:10][NH:11][CH:12]=2)[CH:5]=[CH:4][N:3]=1.[CH:20]1([NH2:23])[CH2:22][CH2:21]1>CO>[CH:20]1([NH:23][C:2]2[N:7]=[C:6]([C:8]3[C:9]([C:13]4[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=4)=[N:10][NH:11][CH:12]=3)[CH:5]=[CH:4][N:3]=2)[CH2:22][CH2:21]1

Participants

4

Reactant 2

HCID 69828CyclopropylamineHCID 178505591HCID 178505591, compound

Product 1

HCID 178505593HCID 178505593, compoundYield 26%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound was synthesized by stirring 2-chloro-4-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]pyrimidine prepared in accordance with Example A-299 with excess cyclopropylamine in methanol at 50° C. for 12 hours. The product, N-cyclopropyl-4-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]-2-pyrimidinamine, was obtained as a white solid in 26% yield, mp: 203-204° C.; Anal. Calc'd for C16H14FN5: C, 65.07; H, 4.78; N, 23.71. Found: C, 64.42; H, 4.82; N, 23.58.

Workup

  1. customThis compound was synthesized

Sources & evidence

ORD record
ord-9d88aa782b324b8a9b210db4e8635da0
Source dataset
uspto-grants-2002_07
Patent number
US06423713B1

Reaction notes

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