Piperidine → HCID 11204538, compound

Participants

Reaction Steps

To diphenylmethyl (S)-3-[(2S,3R,4R,5S)-5-(O-tert-butyl-N-fluorenylmethyloxycarbonyl-L-seryl)amino-2,3,4,6-tetrahydroxyhexanoyl]amino-3-phenylpropionate (874 mg) was added piperidine (5 ml) and the mixture was stirred at room temperature for 5 hours. Removal of the organic solvent gave a residue, which was subjected to flush silica gel column chromatography, followed by elution with methanol-ethyl acetate (1:2). The effective fractions were combined and concentrated under reduced pressure. The residue was recrystallized from diethylether-hexane to afford the title compound (539 mg).

Provenance & Evidence