Acetic Anhydride → HCID 86758379, compound

Participants

Reaction Steps

To a solution of diphenylmethyl (S)-3-[(2S,3R,4R,5S)-5-((N-benzyloxycarbonyl-L-valyl)-L-leucyl)amino-2,3,4,6-tetrahydroxyhexanoyl]amino-3-phenylpropionate (200 mg) in pyridine (1 ml) was added acetic anhydride (0.0243 ml) and the mixture was stirred at room temperature for 14 hours. After concentration under reduced pressure, the residue was passed through silica gel column chromatography, followed by elution with ethyl acetate-methanol (20:1). The effective fractions were combined and concentrated under reduced pressure to give a residue, which was recrystallized from mthanol-diethylether to provide the title compound (103 mg).

Provenance & Evidence