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HRID2230438

反应详情

EQUATION

反应方程式

HRID 2230438 的结构方程式

REACTANTS

反应物

2
结构：O=C(Cl)OCC1c2ccccc2-c2ccccc21
HCID34367

1-(9-Fluorenyl)methyl chloroformate

C15H11ClO2

结构：CC(C)(C)OC(=O)[C@@H]1CCCN2C(=O)CC[C@H](NC(=O)c3ccccc3)C(=O)N12
HCID57166602

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)[C@@H]1CCCN2C(=O)CC[C@H](NC(=O)OCC3c4ccccc4-c4ccccc43)C(=O)N12
HCID67022165

未命名化合物

收率 89%

PROCEDURE

实验过程

was prepared in a similar manner to 211e, except 9-fluorenylmethylchloroformate was used instead of benzoylchloride to give a white glassy solid 211f (2.14 g, 89%): mp 190-192° C.; [α]D25 −81.5° (c 0.1, CH2Cl2). IR (KBr) 3335, 2977, 1731, 1678, 1450, 1421, 1246, 1156, 742; 1H NMR (CDCl3) δ7.60 (2H, m), 7.57 (2H, m), 7.50-7.26 (4H, m), 5.60 (1H, d, J=7.8), 5.28 (1H, m), 4.67 (2H, m), 4.38 (2H, m), 4.23 (1H, m), 3.59-3.41 (1H, m), 2.92-2.65 (2H, m), 2.41-2.21 (2H, m), 1.95-1.58 (4H, m), 1.47 (9H, s). MS(ES−, m/z) 520 (M++1, 97%), 179 (100%).